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Colloquium on the Biology of Aging
August 18 - 20, 2005
Sponsored by the Ellison Medical Foundation and the Marine Biological Laboratory
All seminars are held in the Lillie Auditorium unless otherwise noted.
DRAFT AGENDA as of August 5, 2005, schedule subject to change
| Thursday, August 18 |
| 8:15 - 8:30 |
Introductions |
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| 8:30 - 9:05 |
Marc Tatar, Ph.D., Brown University
The Regulation of Drosophila Aging by Insulin and the Transcription Factor dFOXO
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| 9:05 - 9:40 |
Mark Mayford, Ph.D., The Scripps Research Institute
Mutagenic Screen for Longevity Genes in Mice
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| 9:40 - 10:15 |
Kyung-Tai, Min, Ph.D., National Institute of Neurological Disorders and Stroke, National Institutes of Health
Life Extension of Drosophila by a Drug Treatment |
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| 10:15 – 10:45 |
Break |
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| 10:45 – 11:20 |
David Sinclair, Ph.D., Harvard Medical School
Identification of Genes and Compounds that Extend Yeast Life Span |
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| 11:20 - 11:55 |
Pamela L. Larsen & Catherine F. Clarke, Ph.D., University of Texas Health Science Center at San Antonio; University of California, Los Angeles
Intersection of Two Pathways in Control of Aging: Nutritional Coenzyme Q and DAF-2 Signaling |
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| 11:55 – 1:00 |
Lunch |
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| 1:00 – 1:35 |
Jochen Buck, M.D., Ph.D., Weill Medical College of Cornell University
The Link Between Nutritional Sensing and Aging |
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| 1:35 - 2:10 |
Giuseppe Attardi, M.D., California Institute of Technology
Aging-dependent Large Accumulation of Mutations at Specific Sites in Human Mitochondrial DNA Control Region |
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| 2:10 - 2:45 |
James E. Sligh, Jr., M.D., Ph.D., Vanderbilt University Medical Center, Department of Medicine, and the VA TN Valley Healthcare System
Altered Mitochondrial Function in Transgenic Models of Cutaneous Aging Center for Molecular Medicine |
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| 2:45 - 3:15 |
Break |
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| 3:15 - 3:50 |
Sandy Chang, M.D., Ph.D., M.D. Anderson Cancer Center
Genomic Instability and Aging in Werner-Telomerase Compound Knockout Mice |
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| 3:50 - 4:25 |
Helen M. Blau, Ph.D., Stanford University School of Medicine
Bone Marrow to Brain: Searching for markers of bone marrow stem cells with neurogenic potential |
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| Friday, August 19 |
| 8:00 – 8:35 |
Phyllis M. Wise, Ph.D., University of California Davis
Estradiol is a Neuroprotective Factor in the Aging Brain: Mechanisms of Action |
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| 8:35 - 9:10 |
Wen-Biao Gan, Ph.D., Skirball Institute, New York University School of Medicine
In Vivo Study of Age-related Changes in Synaptic Structure |
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| 9:10 - 9:45 |
Anthony D. Wagner, Ph.D., Stanford University
Age-related Changes in the Functional Neurobiology of Memory |
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| 9:45 - 10:20 |
Fernando Nottebohm, Ph.D., The Rockefeller University
Hypothesis to be tested: some aspects of functional aging result from reduced replacement in the adult CNS |
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| 10:20 - 10:50 |
Break |
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| 10:50 - 11:25 |
Roman Giger, Ph.D., University of Rochester Medical Center
Mechanisms of Neural Plasticity in the Mammalian System |
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| 11:25 - 12:00 |
Yasunori Hayashi, M.D., Ph.D., Massachusetts Institute of Technology
Molecular Mechanism of Rapid Structural Plasticity of Dendritic Spines |
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| 12:00 - 1:00 |
Lunch |
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| 1:00 - 1:35 |
David G. Wells, Ph.D., Yale University
Synaptic Plasticity in the Aging Brain: Role of CPE-dependent Protein Synthesis |
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| 1:35 - 2:10 |
Sangram S. Sisodia, Ph.D., The University of Chicago
Hippocampal Neuroplasticity in Transgenic Mouse Models of Alzheimer's Disease |
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| 2:10 - 2:45 |
Mike Hutton, Ph.D., Mayo Clinic-Jacksonville
In Vivo Analysis of the Role of Tau in Neurodegeneration |
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| 2:45 - 3:15 |
Break |
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| 3:15 - 3:50 |
Lawrence S.B. Goldstein, Ph.D., Howard Hughes Medical Institute at UCSD
Probing the role of axonal transport disturbance and transport-mediated signaling in Alzheimer's Disease |
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| 3:50 - 4:25 |
Robert Sheaff, Ph.D., University of Minnesota Cancer Center
A Mechanistic Explanation for the Development of Neurodegenerative Diseases |
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| 8:00 PM |
Friday Evening Lecture - Linda B. Buck, Ph.D., Fred Hutchinson Cancer Research Center, co-recipient of the 2004 Nobel Prize in Physiology or Medicine - Unraveling the Sense of Smell |
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| Saturday, August 20 |
| 8:00 - 8:35 |
Tamas Bartfai, Ph.D., The Scripps Research Institute
Chronic Neuroprotection During Aging by UCP Mediated Simultaneous Reduction of Free Radical Formation and Exocitotoxicity |
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| 8:35 - 9:10 |
Arnold J. Levine, Ph.D., Institute for Advanced Study
Human Aging SNIP in the P53 Pathway |
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| 9:10 - 9:45 |
Jeffrey S. Friedman, M.D., Ph.D., The Scripps Research Institute
The Role of p66shc in Cellular Senescence and Mammalian Aging |
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| 9:45 - 10:20 |
William A. Mohler, Ph. D., University of Connecticut Health Center
Quantifying Sarcopenic Changes in Aging Muscle by Second-harmonic Generation Imaging |
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| 10:20 - 10:50 |
Break |
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| 10:50 - 11:25 |
Thomas P. Sakmar, M.D., Rockefeller University
The Chromophore Regeneration Pathway in Age-related Macular Degeneration |
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| 11:25 - 12:00 |
John Tower, Ph.D., University of Southern California
Replicative Senescence of Drosophila Stem Cells in Vivo |
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| 12:00 - 12:30 |
Stuart Lipton, M.D., Ph.D., The Burnham Institute
Use of Blood Stem Cells to Regenerate Neurons via the Transcription Factor hMEF2C |
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